Diversity oriented synthesis based on the brevianamide scaffold for the development of physiologically active compounds

01 October 2011 → 30 September 2015
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Organic chemistry
diketopiperazine tryptophane proline brevianamide
Project description

The diketopiperazine scaffold is a preferred (sub)structure in a wide variety of physiologically active natural compounds, including brevianamide F (antibacterial), present in Streptomyces and Aspergillus species. The project aims at the synthesis of heterodiketopiperazine analogues with a less complicated structure than the active natural compounds or the synthesis of diketopiperazines with medicinal relevant substituents starting from amino acids.