Research Explorer

Project

Explaining sepsis severity during E.coli mastitis by a positive feedback mechanism between prostaglandins and cytokines in circulating bovine neutorphils
Code
01J12411
Duration
01 July 2011 → 30 April 2014
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
  • Medical and health sciences
    • Immunology
    • Physiology
    • Immunology
    • Physiology
    • Immunology
    • Physiology
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural and food sciences
Keywords
E.coli mastitis sepsis cytokines prostaglandins
 
Project description
 

Parity and parturition are risk factors for the development of sepsis during E.coli mastitis. The severity of sepsis can be classified into mild, moderate and severe sepsis. We hypothesize that during severe sepsis a positive feedback mechanism exists between prostaglandins (e.g. PGE2) and cytokines (e.g. TNFα) in circulating bovine neutrophils.