Explaining sepsis severity during E.coli mastitis by a positive feedback mechanism between prostaglandins and cytokines in circulating bovine neutorphils

01 July 2011 → 30 April 2014
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
  • Medical and health sciences
    • Immunology
    • Physiology
    • Immunology
    • Physiology
    • Immunology
    • Physiology
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
E.coli mastitis sepsis cytokines prostaglandins
Project description

Parity and parturition are risk factors for the development of sepsis during E.coli mastitis. The severity of sepsis can be classified into mild, moderate and severe sepsis. We hypothesize that during severe sepsis a positive feedback mechanism exists between prostaglandins (e.g. PGE2) and cytokines (e.g. TNFα) in circulating bovine neutrophils.