Project

Multivalent dual-responsive polymeric nanoparticles for targeted anti-cancer therapy

Duration
01 October 2013 → 30 September 2017
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
  • Engineering and technology
    • Chemical product design and formulation
    • Process engineering
    • Polymeric materials
    • Biomaterials engineering
Keywords
polymers drug delivery cancer
 
Project description

In this project we aim to develop a formulation that selectively delivers anti-cancer drugs to cancer cells while minimizing unwanted toxicity to healthy tissue. For this purpose we will encapsulate hydrophobic anti-cancer agents in polymeric nanoparticles thate are engineered with (1) targeting ligands to selectively bind to cancer cells and (2) stimuli-responsive properties to release their drug payload only after cellular uptake.