Inhibition and activation of Natural Killer (NK) cells by alphaherpesviruses

01 January 2015 → 31 December 2020
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Animal immunology
  • Medical and health sciences
    • Innate immunity
    • Virology
herpesvirus herpes simplex NK cells natural killer pseudorabies
Project description

Deficiencies in Natural Killer (NK) cells, central cells in the innate immune response, are associated with severely aggravated herpesvirus disease. NK cell activity is regulated by a complex balance of activating/inhibitory signals. We have recently identified three herpesvirus proteins (gB, gD and US3) that modulate this balance. In the current project, we will identify the mechanism underlying this modulation.