Project

Characterization of the physiological role of the NF-kB and IFN regulatory proteins A20 and DUBA by genetic modification in the mouse.

Duration
01 January 2010 → 31 December 2012
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Immunology
    • Immunology
Keywords
inflammation NF-kappaB signal transduction
 
Project description

A20 and DUBA are two proteins that negatively regulate immune responses, but the physiological role of these proteins in specific tissues or cell types is largely unknown. In this project we aim to study the function of A20 and DUBA via the generation and characterization of cell type specific conditional knockout mice.