Research Explorer

Project

Synthesis of sugar-modified alpha-galactosylceramide analogs as Th1-polarizing NKT-cell antigens
Code
01D36611
Duration
01 October 2011 → 30 September 2015
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Organic chemistry
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
Keywords
synthesis KRN 7000 NKT cells
 
Project description

Synthesis of sugar and sphingosine modified alpha-galactosylceramide (KRN 7000) analogues as NKT cell agonists capable of inducing a Th1-polarised cytokine response. The proposed modifications intend to establish an improved binding affinity to the antigenpresenting CD1d protein, which should result in a bias towards a Th1 respons, as well as an improved aqueous solubility.