Project

Study of the role of A20 (TNFAIP3) and RIPK4 in skin homeostasis and disease.

Duration
01 January 2012 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Dermatology
    • Morphological sciences
    • Oncology
    • Dermatology
    • Morphological sciences
    • Oncology
    • Dermatology
    • Morphological sciences
    • Oncology
Keywords
RIP kinases skin NF-kB A20/TNFAIP3
 
Project description

The skin constitutes a protective barrier and provides a well-balanced response against diverse insults from the environment. The existence of many skin pathologies, underscores the demand for a well-orchestrated keratinocyte differentiation program and for a tight control of skin homeostasis. We want to study the role of the ubiquitin-editing protein A20 and RIPK4 kinase in skin homeostatis, cancer and inflammation.