From Variome to Phenome - an integrated approach towards understanding and treating heritable connective tissue disorders

01 January 2008 → 30 September 2021
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Obstetrics
transgenic animal models gene defects heritable connective tissue disorders molecular singalling pathways
Project description

The general goal of this proposal is (i) to gain a full understanding of the function of selected genes involved in connective tissue diseases and some forms of cancer, both in humans and in animal models, (ii) to study the gnetic basis underlying the phenotypic variation observed in these diseases and (iii) to develop and test new therapeutic strategies for these and related common disorders based on direct targeting of specific cellular pathways.