Ghent University is developing an enzymatic topical treatment for excessive and functionally impairing scar formation resulting from deep burns. Our research team obtained first proof of concept data in vitro and in a validated ex-vivo burn model. The safety of the treatment was proven in a small scale study. We currently explore two enzymes that can be used as monotherapy or as combined treatment. This StarTT aims to obtain further ex-vivo validation data, safety data and clinical in vivo data to strenghten claims in a new patent filing. Application mode will be optimized in terms of dosage, frequency and combination with co-existing general scar treatment. Next to clinical pilot studies, we will perform a market study, investigate the regulatory path and explore a licensing strategy. The main objective is to further develop a non-invasive topical treatment for hypertrophic burn scars improving elasticity and discoloration and to explore the license potential.