Dissecting the molecular network regulating replacement tooth formation in the zebrafish

01 October 2012 → 30 September 2016
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Animal biology
    • Genetics
  • Agricultural and food sciences
    • Veterinary medicine
runx teeth fgf zebrafish
Project description

In this project, we wish to test the hypothesis that the transcription factor runx functions in an fgf signaling loop to regulate the formation of replacement teeth in zebrafish. We will test this hypothesis by (1) manipulating fgf signaling and studying its effects on runx expression and associated phenotype, and (2) manipulating runx expression itself through gain- and loss-of-function approaches.