Project

The role of mitogen-activated protein kinases (MAPK) and their downstream effectoren in transient stress resistance in in vitro produced bovine embryos

Duration
01 October 2010 → 01 October 2011
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
    • Genetics
  • Medical and health sciences
    • Endocrinology and metabolic diseases
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
    • Endocrinology and metabolic diseases
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
    • Nursing
    • Endocrinology and metabolic diseases
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
Keywords
stress embryo stress tolerance
 
Project description

In vitro produced embryos may be subject to (oxidative) stress which is responsible for decreased development and quality of those embryos in comparison with in vivo derived counterparts. Nevertheless, our own FWO-research has shown that short-term exposure of bovine oocytes to an exogenous H2O2-pulse at the end of maturation stimulated embryo development to the blastocyst stage. The aim of this project is to investigate the role of mitogen-activated protein kinases (MAPKs) and proteins such as heat-shock proteins, heat-shock factors, hypoxia-inducible factors, and nuclear factor (NF-kB) in embryo stress tolerance.