Project

Development of in vitro models to study the influence of the microbiota on chemotherapy-induced mucositis in the alimentary tract.

Duration
01 October 2013 → 30 September 2017
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Microbiology
    • Laboratory medicine
    • Laboratory medicine
    • Microbiology
Keywords
oral in vitro microbiota mucositis gastrointestinal
 
Project description

This project focuses on the in vitro effects of irinotecan and 5-fluorouracil on microbiota of the gastrointesinal tract and its lining mucosa using mucositis models and the SHIME (Simulator of the Human Intestinal Microbial Ecology) system. Outcomes will be compared with in vivo results obtained from experiments using the Dark Agouti rat model.