Project

Penetration of antimicrobial agents into biofilms and use of quorum sensing inhibitors as novel anti-biofilm compounds

Code

01G011B9

Duration

01 January 2009 → 30 September 2014

Funding

Regional and community funding: Special Research Fund

Promotor

Jo Demeester

Research disciplines

Natural sciences
- Medicinal and biomolecular chemistry
- Organic chemistry
- Microbiology
- Molecular and cell biology
- Plant biology
- Systems biology
Medical and health sciences
- Biophysics
- Laboratory medicine
- Microbiology
- Molecular and cell biology
- Biophysics
- Laboratory medicine
- Molecular and cell biology
- Biophysics
- Laboratory medicine
- Microbiology
- Molecular and cell biology

Keywords

quorum sensing biofilms drug delivery

Project description

In the present proposal we want to address three specific aims. First of all we want to obtain a clear picture about the ability of antimicrobial agents to diffuse into biofilms. Secondly, we want te develop novel inhibitors of the QS system and evaluate their ability to interfere with microbial biofilm formation. Finally, we want to develop novel carriers for antimicrobial agents (including QSI) in order to increase their efficient delivery into biofilms.