Project

Penetration of antimicrobial agents into biofilms and use of quorum sensing inhibitors as novel anti-biofilm compounds

Duration
01 January 2009 → 30 September 2014
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Medicinal and biomolecular chemistry
    • Organic chemistry
    • Microbiology
    • Molecular and cell biology
    • Plant biology
    • Systems biology
  • Medical and health sciences
    • Biophysics
    • Laboratory medicine
    • Microbiology
    • Molecular and cell biology
    • Biophysics
    • Laboratory medicine
    • Molecular and cell biology
    • Biophysics
    • Laboratory medicine
    • Microbiology
    • Molecular and cell biology
Keywords
quorum sensing biofilms drug delivery
 
Project description

In the present proposal we want to address three specific aims. First of all we want to obtain a clear picture about the ability of antimicrobial agents to diffuse into biofilms. Secondly, we want te develop novel inhibitors of the QS system and evaluate their ability to interfere with microbial biofilm formation. Finally, we want to develop novel carriers for antimicrobial agents (including QSI) in order to increase their efficient delivery into biofilms.