Project

Depressed Skull fractures: Timing of surgery, systemic inflammatory response, surgical site infection, and post-traumatic seizures - (DESTINE Study)

Code

01W03721

Duration

01 October 2021 → 30 September 2026

Funding

Regional and community funding: Special Research Fund

Promotor

Edward Baert

Research disciplines

Medical and health sciences
- Neurosurgery

Keywords

Depressed skull fracture timing of surgery systemic inflammatory responses surgical site infection post-traumatic epilepsy

Project description

The timing for surgery of depressed skull fracture (DSF) in low-income-countries remains unclear due to the risks from the intraoperative bleeding versus surgical site infection. Neuro-inflammation induced by trauma, anaesthesia, and surgery stress predispose patients to late post-traumatic epilepsy. Indepth immunological, imaging, and clinical studies of patients with DSF could improve the understanding and decision-making of the surgical timing.