Project

Investigation of the ARF/MDM2/p53 signaling pathway in cancer cells by means of miRNA analysis and RNA interference screening

Duration
01 January 2009 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
Keywords
microRNA neuroblastoma cancer
 
Project description

This project contains 3 research themes: 1) study of microRNA 34b/c as mediators of the p53 responses and identification of microRNAs involved in nutlin-3 induced differentiation and scenesence, 2) Identification of oncogene addiction, synergistic lethality with nutlin-3, p53 signaling inhibitors and synthetic lethality with p53 deficiency through siRNA screening, and 3) functional analysis of p53 modulators