Project

Study of nuclear receptor-based cross-talk mechanisms in the combat against inflammation

Duration
01 October 2007 → 30 September 2012
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
  • Engineering and technology
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
Keywords
PPAR glucocorticoids Inflammation
 
Project description

At present, as a means to circumvent a subset of glucocorticoid (GC)-associated side effect, the focus of my work not only includes the unravelling of fundamental Glucocorticoid receptor (GR)-mediated transrepression mechanisms but also includes a mechanistic study of non-steroidal dissociated GR ligands.

Apart from this, I study the applicability of another way of skewing therapeutic responses towards a more desirable profile, by using dual nuclear receptor triggering. This involves combination schemes using GR agonists combined with Peroxisome Proliferator-Activated Receptor (PPAR) agonists.