The current project focusses on the synthesis of photo-responsive (bio)polymers including hydrogels and polyesters to be exploited in tomographic volumetric printing and two-photon polymerization serving medical applications such as cell carriers for tissue engineering, drug delivery devices and organ-on-chip. In addition, we will exploit these light-based 3D-printing techniques to spatially graft bioactive molecules (such as cell-interactive peptides) during 3D printing or throughout a previously printed material. In parallel, we will also explore multi-material 3D printing offering the capability of combining mechanical strength of synthetic polymers with the cell-interactive properties of natural polymers such as gelatin. In addition to conventional thiol-ene step growth crosslinkable polymers, we will also explore bifunctional polymer derivatives combining irreversible and reversible bonds – the latter being interesting to tune stress relaxation properties of the scaffolds.