Project

Alterations in hepatic drug metabolism in children with severe chronic liver disease and in pediatric liver transplant recipients

Code

01J03608

Duration

01 January 2008 → 31 October 2012

Funding

Regional and community funding: Special Research Fund

Promotor

Jan Van Bocxlaer

Research disciplines

Medical and health sciences
- Pediatrics and neonatology
- Pediatrics and neonatology
- Nursing
- Biomarker discovery and evaluation
- Drug discovery and development
- Medicinal products
- Pharmaceutics
- Pharmacognosy and phytochemistry
- Pharmacology
- Pharmacotherapy
- Toxicology and toxinology
- Other pharmaceutical sciences
- Pediatrics and neonatology

Keywords

liver disease liver transplantation pediatrics drug metabolism pharmacokinetics

Project description

This project aims to evaluate the differential alterations in hepatic drug metabolism in children with severe chronic liver disease and in pediatric liver transplant recipients, using both in vitro (liver microsomes from surgical waste) and in vivo (probe-cocktail) approaches.