Research Explorer

Project

Alterations in hepatic drug metabolism in children with severe chronic liver disease and in pediatric liver transplant recipients
Code
01J03608
Duration
01 January 2008 → 31 October 2012
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Paediatrics and neonatology
    • Paediatrics and neonatology
    • Nursing
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
    • Paediatrics and neonatology
Keywords
liver disease liver transplantation pediatrics drug metabolism pharmacokinetics
 
Project description
 

This project aims to evaluate the differential alterations in hepatic drug metabolism in children with severe chronic liver disease and in pediatric liver transplant recipients, using both in vitro (liver microsomes from surgical waste) and in vivo (probe-cocktail) approaches.