Code
3G022609
Looptijd
01-01-2009 → 31-12-2014
Financiering
Research Foundation - Flanders (FWO)
Promotor
Onderzoeksdisciplines
-
Natural sciences
- Biochemistry and metabolism
- Microbiology
-
Medical and health sciences
- Dermatology
- Medical biochemistry and metabolism
- Microbiology
- Dermatology
- Medical biochemistry and metabolism
- Microbiology
- Dermatology
- Medical biochemistry and metabolism
- Microbiology
-
Agricultural and food sciences
- Veterinary medicine
Trefwoorden
epidermale differentiatie
caspase
keratinocyt
Projectomschrijving
The epidermis, which forms the uppermost, multilayered compartment of the skin, has evolved to provide a physical and permeability barrier, which is essential for survival and to prevent microbial invasion. Our work has shown that caspase-14 plays an important role in the correct formation of the skin barrier. Now we want to investigate the molecular mechanisms leading to this phenotype, using different in vivo model systems.