Duration
01 January 2009 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
-
Natural sciences
- Biochemistry and metabolism
- Microbiology
-
Medical and health sciences
- Dermatology
- Medical biochemistry and metabolism
- Microbiology
- Dermatology
- Medical biochemistry and metabolism
- Microbiology
- Dermatology
- Medical biochemistry and metabolism
- Microbiology
-
Agricultural and food sciences
- Veterinary medicine
Keywords
epidermal differentiation
keratinocyte
caspase
Project description
The epidermis, which forms the uppermost, multilayered compartment of the skin, has evolved to provide a physical and permeability barrier, which is essential for survival and to prevent microbial invasion. Our work has shown that caspase-14 plays an important role in the correct formation of the skin barrier. Now we want to investigate the molecular mechanisms leading to this phenotype, using different in vivo model systems.
