Project

Gamma-glutamyl transpeptidase as a major virulence factor of Helicobacter suis: mechanisms leading to epithelial cell necrosis and immune modulation

Duration
01 October 2012 → 01 October 2014
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Animal biology
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Gastro-enterology and hepatology
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Gastro-enterology and hepatology
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Gastro-enterology and hepatology
    • Immunology
    • Laboratory medicine
    • Microbiology
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
Keywords
helicobacter suis gammaglutamyl transpeptidase immune modulation virulence mechanisms cell necrosis
 
Project description

Helicobacter suis is the most prevalent non-Helicobacter pylori Helicobacter species in humans suffering from gastric disease. We aim to unravel the mechanisms used by this bacterium and its gamma-glutamyl transpeptidase to cause gastric epithelial cell death on one hand and to modulate the host immune response on the other hand.