Macrocyclic lactone resistance in the bovine abomasal ematode OStertagia ostertagi

01 January 2008 → 31 December 2010
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Animal biology
    • Microbiology
  • Medical and health sciences
    • Microbiology
    • Microbiology
    • Microbiology
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
nematodes resistence anthelmintics parasites
Project description

To elucidate the molecular mechanisms of macrocyclische lactone-resistance in the bovine parasite Ostertagia ostertagi, the genetic polymorphism in the P-glycoprotein A, glutamate-gated chloride channel subunit alfa 3 and beta-tubulin isotype 1 genes will be investigaed in ML-susceptible and resistant isolates of O, ostertagi, a Molecular tests will be developed to detect specific mutations or increased transcription levels associated with ML-resistance.