General purpose
The general aim is the biological discovery and characterization of new bioactive substances from marine biological ones
sources from local North Sea species.
Concrete goals and criteria
The first aim is to establish a reproducible and extensible high-throughput analytical screening of
extracts in combination with multi-target bioactivity and toxicity tests. Based on this, next
objectives pursued:
1) The identification and collection of 50 North Sea species that are potentially bioactive substances with a commercial
potential and develop "Bio-prospecting index cards" with a summary of the existing ones
information from these species about potential components, cultivation possibilities and spatial / seasonal
spread.
2) The high-throughput screening of extracted components and the creation of an open source database,
structured and analytical (mass spectral) data and bioactivity of the components and others
Flanders
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metadata related to marine organisms, which will be of great value to both
Industry as the research community.
3) The identification of pharmacological targets for the selected bioactive compounds with a
commercial potential through research based on high-throughput bioassays.
4) The high-throughput screening of the antimicrobial activity of extracts from North Sea species, which is a
inhibit biofilm formation of the biofilm.
5) The identification of promising applications of marine bioactive substances and the stimulation of new ones
follow-up innovation projects for biorefining, aquaculture and biotech applications in Flanders, by the
integration of actors from industry and knowledge institutions.