A shift towards a more circular economy is crucial to achieve more sustainable and inclusive growth. Our objective is to provide local and regional authorities with an innovative transdisciplinary open source geodesign decision support environment (GDSE) developed and implemented in living labs in six metropolitan areas. The GDSE allows creating integrated, place-based eco-innovative spatial development strategies aiming at a quantitative reduction of waste flows in the strategic interface of peri-urban areas. These strategies will promote the use of waste as a resource, thus support the on-going initiatives of the EC towards establishing a strong circular economy.