Code
01D00109
Looptijd
01-10-2009 → 01-10-2010
Financiering
Regional and community funding: Special Research Fund
Promotor
Onderzoeksdisciplines
-
Social sciences
- Biological and physiological psychology
- Cognitive science and intelligent systems
- Developmental psychology and ageing
-
Medical and health sciences
- Neurosciences
- Neurosciences
- Neurosciences
Trefwoorden
pilocarpine
norepinephrine
nervus vagus stimulatie
temporale kwab epilepsie
locus coeruleus
Projectomschrijving
The aim of this project is to elucidate the role of the locus coeruleus and the hippocampol noradrenergic transmission in the anti-epileptic effects of VNS in the intrahippocampal pilocarpine model, and to define the activation of hippocampal noradrenergic transmission as biomarker for efficacy of VNS. Therefore, we make us of selective leasies, specific antagonists and state-of-the-art neurophysiological technics.