Vagus nerve stimulation (VNS) in a focal epilepsy model: a microdialysis study on the role of norpinephrine and neuropeptide Y

01 October 2009 → 01 October 2010
Regional and community funding: Special Research Fund
Research disciplines
  • Social sciences
    • Biological and physiological psychology
    • Cognitive science and intelligent systems
    • Developmental psychology and ageing
  • Medical and health sciences
    • Neurosciences
    • Neurosciences
    • Neurosciences
locus coeruleus norephinephrine temporal lobe epilepsy vagus nerve stimulation pilocarpine
Project description

The aim of this project is to elucidate the role of the locus coeruleus and the hippocampol noradrenergic transmission in the anti-epileptic effects of VNS in the intrahippocampal pilocarpine model, and to define the activation of hippocampal noradrenergic transmission as biomarker for efficacy of VNS. Therefore, we make us of selective leasies, specific antagonists and state-of-the-art neurophysiological technics.