Code
01J09611
Duration
01 July 2011 → 30 April 2016
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Medicinal and biomolecular chemistry
- Molecular and cell biology
- Plant biology
- Systems biology
-
Medical and health sciences
- Biophysics
- Molecular and cell biology
- Physiology
- Biophysics
- Molecular and cell biology
- Physiology
- Biophysics
- Molecular and cell biology
- Physiology
Keywords
electrophysiology
gap junctions
organ ischemia
Project description
This study aims to better understand the regulation of connexin hemichannels, which are half non-connected gap junction channels in the plasma membrane. Hemichannel opening can lead to cell injury/death. We use patch-clamp techniques for a detailed analysis of the effect of intramolecular interactions on channel behaviour. The results are essential in the development of selective hemichannel inhibitors for therapeutic application in cardiac ischemia.