Research Explorer

Project

Danger-associated molecular patters: revealing the molecular signals dictating the communication between dying cells with the immune system
Code
3G072810
Duration
01 January 2010 → 31 December 2015
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Morphological sciences
    • Oncology
    • Immunology
    • Morphological sciences
    • Oncology
    • Immunology
    • Morphological sciences
    • Oncology
Keywords
necrosis DAMPs immunogenic cell death autophagi cell death calreticulin apoptosis TLRs
 
Project description
 

Defective interactions of dying cells with the innate and adaptive immune system contribute to the development of cancer and autoimmunity. The main goal of current project is to study the mechanisms behind immunogenicity of cell death pathways induced by various cytotoxic agents (including ROS-based strategies such as PDT) and to further strengthen the “anticancer vaccine effect” concept.