When manufacturing oral solid dosage forms via integrated continuous production lines, continuous blending of API and excipients is an essential aspect of the process. However, the impact of material properties on the performance of a continuous blending process is currently poorly understood. This project aims to link the properties of materials (active pharmaceutical ingredients, fillers) with their behavior during continuous blending using a continuous linear in-line blender. Following a full characterization of the materials, experimental blending studies using different APIs and fillers will allow to identify the material properties which define the behavior of a material during continuous blending. The final outcome of the project will be a model which allows to predict the blending behavior of a material based on its properties, i.e. defining the optimal parameters (throughput, blender configuration, blending speed, formulation composition) required to achieve optimal homogeneity of the blend.