Study of the phosphoenpyruvate-pyruvate-oxalacetate node in Eschericia coli based on multi-omics data and mathematical models

01 October 2007 → 30 September 2011
Regional and community funding: Special Research Fund
Research disciplines
  • Engineering and technology
    • Biocatalysis and enzyme technology
    • Bioprocessing, bioproduction and bioproducts
    • Fermentation
    • Industrial biotechnology diagnostics
    • Industrial microbiology
    • Industrial molecular engineering of nucleic acids and proteins
    • Industrial biotechnology not elsewhere classified
biotechnology modelling metabolic engineering transcriptomics metabolomics
Project description

This project has a goal to elucidate on of the most important nodes in industrial biotechnology, the PEP-pyruvate-oxalacetate node. By means of 13C-labellingsexperiments and transcriptome data, the intracellular fluxes will be uncovered. For this purpose, novel sampling and analytical protocols will be set up, after which experimental data can be collected as a basis for mathematical models.