The research proposal is strategically positioned at the intersection of innovative technology and molecular genetics. It leverages massively parallel sequencing technologies to pioneer advancements in next-generation sequencing (NGS) methodologies, encompassing the analysis of both DNA and RNA sequences across diverse organisms. The proposed studies aim to dissect genomic and transcriptomic dynamics within a broad spectrum of biological and clinical settings.

Key areas of investigation include the characterization of intra- and extracellular RNA signals. Additionally, the research explores the development of novel DNA probes for hybridizing to tandem repeats in genomic DNA, illustrating the versatility of NGS from foundational science to clinical applications. The project also delves into pharmacogenetics with the goal of personalizing medical treatments based on individual genetic profiles, thereby boosting therapeutic efficacy and safety.

A pivotal component of this research involves the application of sophisticated bioinformatics tools designed to decode complex sequencing data. These innovative tools are essential for conducting detailed genetic analyses.