Project

Study of 2-substituted 2-(bromomethyl)aziridines as flexible synthons in heterocyclic chemistry

Duration
01 December 2011 → 30 November 2012
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Organic chemistry
Keywords
aziridinium iones ring opening regio- and stereoselectivity ring transformation aziridines
 
Project description

The aziridine moiety represents one of the most valuable three-membered building blocks in organic synthesis. This PhD-project comprises the preparation and use of 2-substituted 2-(bromomethyl)aziridines as novel synthons in heterocyclic chemistry. Particular attention will be paid to the study of regio- and stereoselective ring-opening reactions and ring transformations towards biologically relevant target compounds.