Project

Influence of prebiotics on pre-emptic colonisation and resulting protection against bacterial infections of the intestine in an optimized in vitro model

Duration
01 October 2007 → 30 September 2011
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Laboratory medicine
    • Microbiology
    • Laboratory medicine
    • Laboratory medicine
    • Microbiology
Keywords
intestinal pathogens mucus bacterial adhesion
 
Project description

Before intestinal pathogens cause infections, they need to attach and pnetrate the mucus layer, so they can adhere to the epithelium. A little studied effect of prebiotics is their potential to reduce the adhesion of pathogens. For this research several in vitro methods will be developed such as the extension of the SHIME with a module to simulate the intestinal surface.