Bacterial infection remains an important threat to dermal wounds, including difficult-to-heal diabetic, chronic wounds. It is known that excessive amounts of reactive oxygen species (ROS), especially generated during bacterial infection, further impede wound healing. Within the proposed PhD project, a novel stimuli-responsive polymer-based, adhesive, and stretchable dermal matrix will be developed which will support wound healing via: i) the controlled delivery of antibacterials, triggered by excessive ROS, following infection, ii) promoting the migration of endothelial cells towards the wound site, iii) maintaining the moisture balance and iv) scavenging excessive ROS which impairs wound healing. Multi-stimuli (thermo- and ROS-) responsive polymersomes will be developed to enable controlled drug delivery. The polymersomes will be incorporated in a ‘nature-derived’ photocrosslinkable dermal matrix. The polymer matrix will be designed such, to ensure cell adhesion, adhesivity to the wound as well as stretchability which would enable the applicability at challenging body parts accompanied by frequent motion and bending. The dermal matrix, containing incorporated polymersomes, will be processed using electrospinning, creating a microfibrous construct able to ensure breathability and to control the moisture balance. The herein proposed smart system would lead to a major leap forward regarding the treatment of chronic, diabetic wounds.