Project

Targeting the Tumor Microenvironment in Colorectal Peritoneal Metastases

Duration
01 January 2021 → Ongoing
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
  • Medical and health sciences
    • Immunology not elsewhere classified
    • Cancer therapy
    • Oncological surgery
Keywords
Peritoneal carcinomatosis colorectal cancer immune therapy TLR agonist
 
Project description

Toll-like receptor (TLR) agonists can fuel the immune system in the fight against cancer. For peritoneal cancer of colorectal origin (CRC), however, immune therapy is still in its infancy. We will characterize the peritoneal immune microenvironment in patients with CRC, develop a TLR-agonist therapy for local peritoneal administration and investigate the effect of TLR activation on cancer- associated fibroblasts and epithelial-to-mesenchymal transition in cancer cells.