Recent drug improvement (e.g. abiraterone or enzalutamide) for castration resistant prostate
cancer (CRPC) patients has improved survival. As treatment strategies improve and patients live
longer, patients must cope with their treatment-induced adverse effects. Improving levels of
physical activity (PA) and less amounts of sitting time (e.g. sedentary behavior, SB) could have a
positive impact on patient’ health, non-cancer mortality, and quality of life and potentially
Despite the health benefits, only the minority of prostate cancer patients performs sufficient levels
of PA and the majority has high amounts of SB. To date, few studies have focused on CRPC
patients resulting in a knowledge gap of the potential of exercise interventions for CRPC patients.
At first, a pilot study will be conducted, as specific exercise prescription for our study population is
not known. The main study is an intervention study to evaluate the effectiveness of exercise and
life style advice for CRPC patients receiving abiraterone or enzalutamide on cardiorespiratory
fitness. Finally, a qualitative study will be done to explore patient’ experiences and attitudes
towards the intervention.