Recent drug improvement (e.g. abiraterone or enzalutamide) for castration resistant prostate

cancer (CRPC) patients has improved survival. As treatment strategies improve and patients live

longer, patients must cope with their treatment-induced adverse effects. Improving levels of

physical activity (PA) and less amounts of sitting time (e.g. sedentary behavior, SB) could have a

positive impact on patient’ health, non-cancer mortality, and quality of life and potentially

improve survival.

Despite the health benefits, only the minority of prostate cancer patients performs sufficient levels

of PA and the majority has high amounts of SB. To date, few studies have focused on CRPC

patients resulting in a knowledge gap of the potential of exercise interventions for CRPC patients.

At first, a pilot study will be conducted, as specific exercise prescription for our study population is

not known. The main study is an intervention study to evaluate the effectiveness of exercise and

life style advice for CRPC patients receiving abiraterone or enzalutamide on cardiorespiratory

fitness. Finally, a qualitative study will be done to explore patient’ experiences and attitudes

towards the intervention.