Project

Study of the functional role of the distinct lung nd liver antigen-presenting cells subsets in vivo.

Acronym

Role of Alveolar MFs

Code

41MC1212

Duration

01 March 2012 → 28 November 2016

Funding

European funding: framework programme

Promotor

Bart Lambrecht

Research disciplines

Medical and health sciences
- Immunology
- Respiratory medicine
- Immunology
- Microbiology
- Respiratory medicine
- Immunology
- Respiratory medicine

Keywords

kupffer cells asthma monocytes dendritic cells macrophages immunoregulation alveolar macrophages

Project description

Dendritic Cells (DCs) and MFs present antigens to T cells, which differentiate into Effector or Regulatory T cells. Some DCs or MFs may preferentially induce tolerance through Regulatory T cells, while others may preferentially induce Effector T cells. We will study the role of distinct DCs and MFs by restricting antigen-presenting-capacity to one DC or MF subset at a time.