Exosome-inspired nanocarriers for the delivery of small interfering RNA

01 October 2012 → 30 September 2016
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
  • Engineering and technology
    • Chemical product design and formulation
    • Biomaterials engineering
exosomes gene therapy siRNA nanoparticles
Project description

Drug delivery across intra-and extracellular barriers remains a major bottleneck in the clinical application of siRNA. To overcome these hurdles, siRNAs need to be packaged in nanosized drug carriers. An exciting new research area involves using cell-derived microvesicles (e.g. exosomes) as delivery tool for macromolecular therapeutics. The major objective is to evaluate exosomes and exosome-mimetic nanoparticles for siRNA delivery