Research Explorer

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Project

Exosome-inspired nanocarriers for the delivery of small interfering RNA

Outputs and Outcomes

Code

3F024012

Duration

01 October 2012 → 30 September 2016

Funding

Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)

Promotor

Stefaan De Smedt

Fellow

Stephan Stremersch

Research disciplines

Engineering and technology
- Particle design and technology

Keywords

exosomes gene therapy siRNA nanoparticles

Project description

Drug delivery across intra-and extracellular barriers remains a major bottleneck in the clinical application of siRNA. To overcome these hurdles, siRNAs need to be packaged in nanosized drug carriers. An exciting new research area involves using cell-derived microvesicles (e.g. exosomes) as delivery tool for macromolecular therapeutics. The major objective is to evaluate exosomes and exosome-mimetic nanoparticles for siRNA delivery

English

Dutch

English

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