Code
3F024012
Duration
01 October 2012 → 30 September 2016
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Medical and health sciences
- Biomarker discovery and evaluation
- Drug discovery and development
- Medicinal products
- Pharmaceutics
- Pharmacognosy and phytochemistry
- Pharmacology
- Pharmacotherapy
- Toxicology and toxinology
- Other pharmaceutical sciences
-
Engineering and technology
- Chemical product design and formulation
- Biomaterials engineering
Keywords
exosomes
gene therapy
siRNA
nanoparticles
Project description
Drug delivery across intra-and extracellular barriers remains a major bottleneck in the clinical application of siRNA. To overcome these hurdles, siRNAs need to be packaged in nanosized drug carriers. An exciting new research area involves using cell-derived microvesicles (e.g. exosomes) as delivery tool for macromolecular therapeutics. The major objective is to evaluate exosomes and exosome-mimetic nanoparticles for siRNA delivery