Project

Catalytic carbonylation of aziridines to novel beta-lactams as versatile building blocks in heterocyclic chemistry

Duration
01 March 2013 → 31 December 2017
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Organic chemistry
Keywords
carbonylation beta-lactams aziridines catalysis
 
Project description

This project aims at the implementation of homogenous catalysis as a key stap in the synthesis of novel heterocyclic compounds with biological interest. In particular, functionalized aziridines will be evaluated as substrates for a catalytic carbonylation to provide the corresponding beta-lactams. The latter type of beta-lactams will then serve as new building blocks for the construction of a variety of biologically relevant heterocycles such as pyrrolidines, pyrrolidinones, pyrroles, oxolanes, piperidines, and bi- and tricyclic beta-lactams.