Project

Study on the effects of HDAC inhibitors on the transcriptional activity of the glucocorticoid receptor.

Duration
01 January 2016 → 31 December 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Endocrinology and metabolic diseases
    • Immunology
    • Endocrinology and metabolic diseases
    • Immunology
    • Microbiology
    • Endocrinology and metabolic diseases
    • Immunology
Keywords
regulation of gene expression sepsis glucocorticoids
 
Project description

In the lab, a chemical compounds screening was used to detect molecules that stimulate the GR dimere pathway. This screening showed that different HDAC inhibitors strongly enhanced the activity of the GR. In this project, these HDACi will be investigated further, to decide if these molecules are applicable in th clinic to enhance the GC activity and to reverse the GC resistance in sepsis patients.