Project

Characterization of the in vivo role of MALT1 proteolytic activity in inflammation and immunity

Duration
01 October 2008 → 31 March 2011
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Immunology
    • Microbiology
    • Immunology
Keywords
transgenic mice inflammation MALT1
 
Project description

Lymphocyte activation plays a critical role in immune responses and a defect results in severe immune deficiencies/lymphoma. The paracaspase MALT1 is of special interest, although the mechanism by which MALT1 triggers NF-kB activation is still largely unclear. The aim of this project is to study, by using newly generated mouse models, (1) MALT1 inactive and (2) MALT1 resistant A20, and also analyze the effect of MALT1 peptide inhibitors.