Towards a better understanding of the link between molecular mechanisms and macroscopic effects in nanosuspension formulation

01 January 2010 → 31 December 2013
Regional and community funding: IWT/VLAIO
Research disciplines
  • Natural sciences
    • Analytical chemistry
  • Medical and health sciences
    • Pharmaceutical analysis and quality assurance
Project description

The objective of this project is to build a knowledge platform on the impact of the formula composition and production at the properties of nano-suspensions. The project is aimed in the first instance is to be prevented a better understanding of the (determinants) physico-chemical stability of nano-suspensions and the in-vitro release kinetics, with a gradual increase in mean diameter. Sedimentation and opschudbaarheid will also be also taken into consideration. It will also be fed back with the results of (a more limited number of wells in which) in-vivo experiments, which will be set up by the industrial promoter. On the basis of the obtained findings will be developed a theoretical framework for the one hand, not only to understand the sensitivity with respect to physicochemical instability, but also to be able to predict them. On the other hand, a theoretical model is necessary to predict the extent and rate of dissolution of the active component.