Project

Epigenetic re-activation of T-ALL tumor suppressors under control of TLX1driven enhancer RNAs.

Duration
01 October 2015 → 30 September 2019
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
    • Other biological sciences
  • Medical and health sciences
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
Keywords
TLX1 T-ALL enhancers epigenetics lncRNAs
 
Project description

In this project, I will further explore the oncogenic role of TLX1 in the development of T-cell acute lymphoblastic leukemia. This research will explore a network connecting TLX1 with long noncoding RNAs and tumor suppressor genes. Ultimately, this should allow identification new vulnerable nodes for targeted therapy of TLX1-driven T-ALLs.