Project

Molecular and biochemical characterization of the globin gene family in Caenorhabditis elegans

Duration
01 October 2008 → 30 November 2009
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Animal biology
    • Biochemistry and metabolism
    • General biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
gene expression globins C. elegans
 
Project description

In silico analysis revealed the presence of 33 globin genes in the genome of C. elegans. The purpose of the project is to unravel their functions. Therefore the following approaches will be performed: Localisation of expression using GFP-reporter constructs. Expression profiling under hypoxia. Phenotype analysis under gene silencing. Identification cloning of a subset of globins and subsequent biochemical study of their ligand binding characteristics.