The role of nucleocytoplasmic glycosylation in protein degradation

01 October 2007 → 30 September 2015
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
  • Engineering and technology
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
F-box proteins N-glycosylation lectins
Project description

In animal models, it has been shown that N-glycosylation can be a prerequisite for targeting of glycoproteins for degradation. In this process sugar-binding F-box proteins (or Fbs proteins) are involved. Homologous nucleocytoplasmic F-box proteins have been discovered in plants. In this project, putative Fbs proteins from plants will be functionally characterized and compared with the animal Fbs proteins.