Project

Study of the interaction between the dopamine D2-like receptors and the μ opioid receptor

Duration
01 January 2015 → 31 December 2020
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • General biology
    • Plant biology
Keywords
opioid receptor dimer dopamine receptor bivalent ligand GPCR pain
 
Project description

Dopamine and μ-opioid receptors, two GPCRs, play a major role in pain and addiction. We will evaluate the direct interaction between these GPCRs in native tissue. Next we will study the effect on ligand binding and signal transduction. Towards this end we will develop heterobivalent ligands, which are able to bind both receptors at

the same time.