Research Explorer

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Project

Study of the interaction between the dopamine D2-like receptors and the μ opioid receptor

Outputs and Outcomes

Code

3G021715

Duration

01 January 2015 → 31 December 2020

Funding

Research Foundation - Flanders (FWO)

Promotor

Serge Van Calenbergh

Research disciplines

Natural sciences
- General biology
- Plant biology

Keywords

opioid receptor dimer dopamine receptor bivalent ligand GPCR pain

Project description

Dopamine and μ-opioid receptors, two GPCRs, play a major role in pain and addiction. We will evaluate the direct interaction between these GPCRs in native tissue. Next we will study the effect on ligand binding and signal transduction. Towards this end we will develop heterobivalent ligands, which are able to bind both receptors at

the same time.

English

Dutch

English

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