Code
3E014310
Duration
01 October 2010 → 30 November 2016
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Medical and health sciences
- Immunology
- Orthopaedics
- Immunology
- Orthopaedics
- Immunology
- Orthopaedics
Keywords
arthritis
immunology
regulatory T cells
Project description
Invariant natural killer T cells (iNKT) and CD4+CD25+FOXP3+ regulatory T cells (Tregs) are important thymus-derived immunomodulatory cells. In this project, we aim to evaluate the functional interaction between these immunomodulatory cells in patients with rheumatic disorders. Furthermore, the cooperation of iNKT cells and Tregs under inflammatory conditions will be evaluated in an animal model of TNF mediated arthritis.